How Does Kratom Work In Body?

What is Kratom

It is important to start this section by defining what Kratom is. Kratom is a tropical plant of the family from Mitragyna speciosa family nature to Southeast Asian countries e.g Thailand, Indonesia, Malaysia among others. It has opiod-like activities, specifically morphine and has since found its use in medicine practice. It has several health benefits, some of which were exhausted by its traditional users.

Kratom leaves are responsible for producing the health benefits that we will be discussing shortly. Conversely, the stem has also been shown to have medicinal benefits.

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It is important to note that Kratom is a non-prescription herbal medication that has found its use in many countries. It is sold as leaves, crushed powder, capsules, and gum. It can also be chewed, smoked or used as a beverage.

Kratom leaves are either white, red or green. Each of these produce different strains with different pharmacokinetics and pharmacodynamics.

Kratom has been banned in several countries like Australia, Malaysia and Myanmar. However, there is an increasing use of Kratom in the US and some European countries despite the fact that it has not been authorised.

How Does Kratom Work In Body?

  • Kratom contains more than 40 alkaloids that act on opiod and monoaminergic receptors but structurally different from opions. The two major alkaloids: Mitragynine and 7-hydroxy-Mitragynine.
  • Basically Kratom acts as an opioid receptor agonist with almost similar effects like morphine and opiod.
  • This happens despite the fact that the two are very distinct structurally.
    Normally, opiods potentiate their effects by binding to and activating their receptors. This results in their euphoric, pain relieving, antiinflammatory and anxiolytic effects. Researchers link opiod effects to mimicry of endogenous opiods like enkephalins, endorphins and dynorphins. These peptides just like opiods are known to reduce pain, sedate and cause a feeling of pleasures.
  • The Psychoactive alkaloids in kratom: Mitragynine and 7hydroxymitragynine have been shown to bind as partial agonists to the μ-opioid receptors and antagonistic to the κ- and δ-opioid receptors.
    They have high binding affinities to the µ- and κ-receptors. 7-hydroxymitragynine shows high affinity for δ-receptors than Mitragynine.
  • One of the difference between opiods and Kratom, is that kratom,, specifically Mitragynine has very high affinity for kappa receptors. Unlike opiods, ktratom also act as an agonist at norepinephrine and serotonin receptors. Its action on norepinephrine and serotonin is believed to be a contributor in kratom’s stimulation effects.
  • In addition, kratom has been said to contains alkaloids: rhynchophylline and mitraphylline that are NMDA receptor antagonists. This too is believed to have a place in its action.
  • It is worthwhile to mention that the effects of kratom are dose-dependent. Whereas low doses have been demonstrated to produce stimulatory effects resembling the stimulant effect of drugs such as cocaine or amphetamines, higher dosages tend to be associated with sedative-narcotic effects that resemble drugs such as opiates.
  • This possibly is due to what others say, that at low to moderate doses, Mitragynine has acts on highly on kappa and delta receptors, and at very higher doses the affinity changes to mu-receptors.
  • Despite the fact that kratom contains lower levels of 7-hydroxymitragynine than mitragynine, it has been suggested by some authors that 7-hydroxymitragynine is more potent and has better oral bioavailability and blood brain-barrier penetration than mitragynine. This again, can only be proved by enough studies and research on Kratom.
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What are the benefits of Kratom powder?

Kratom is a stimulant

Like it has earlier been indicated, Kratom effects are dose-dependent. Just like opiods Kratom, specifically Mitragynine is a stimulant although at low doses. At low doses, Mitragynine acts majorly on the delta and kappa receptors resulting into the stimulatory effects.

Kratom users report being very euphoric and have a feeling of well being after taking kratom. They report to be very positive about everything around them.

Just to mention, some argue that kratom is a hallucinogen, this is utterly wrong. This is a notion advanced by anti-kratom crusaders backed with no evidence or facts. They can better be ignored.

Kratom has anti-inflammatory properties

Kratom like opiods has been used widely as an anti-inflammatory medication. While there are no maximum research to back this, users report that it’s very effective in managing inflammation.
Different authors argue that it produces it’s anti-inflammatory action through different mechanisms. One such mechanism, is it’s suppressive role on prostaglandin E2 production in the cyclooxygenase 2 (COX-2) pathway.

Has Anti-convulsant effects

Kratom has also been used before by patients with seizures. It proved very promising. It is not yet clear how kratom modulate this effects.

However, there are proposals that kratom could be acting on certain areas of the brain that are responsible for coordination. Yet some authors and researchers believe that Mitragynine could be modulating the sympathetic tone of muscles.

Kratom for Anxiety

Kratom has also been shown to possess anxiolytic properties. It does this possibly by modulating body hormones and soothening nerves. This however is subject to confirmation from a research point of view.
Other researchers believe that kratom anxiolytic action could be due to psychostimulative actions of the endogenous peptides like endorphins.

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Users of Kratom reports being very relaxed after smoking or chewing Kratom.

Diabetes treatment

Some researchers also believe that kratom is important in regulating blood sugar levels. They suggest that kratom controls the blood levels of insulin and glucose helping those with diabetes to manage the condition well.

Energy booster

Kratom adds vitality to the body which elevates the energy levels. Kratom users reports increased stamina and strength.

Relieves pain

Kratom has widely been used as pain relieves. It relieves pains by impacting on the normal system of the body. Preliminary studies have shown that the levels of serotonin and dopamine increases immensely when kratom leaves are chewed. This adds to the pain relieving property.

Use to manage opiate withdrawal

Some authors argue that kratom can be used to manage opiate withdrawal symptoms. Although, there are no scientific facts to back this, common sense and user experience can make one believe so.
We have indicated that kratom has effects similar to those of other opiods. It has agonistic action at mu and delta Opiate receptors.

Unlike opiates, it doesn’t produce long-term dependency. It helps in restoring ones appetite. Just like we discussed above, it elevates mood and has an anti-anxiety action. Remember opiate withdrawal is linked to mood swings and anxiety.

Some others claim there is evidence that kratom helps in reducing insomnia and pain- related symptoms of Opiate withdrawal.

Moreover, some researchers have it that kratom reduces, vomiting, and nausea associated with Opiate withdrawal.

Kratom has anti-diarrheal properties

Kratom acts by activating the sympathetic nervous system. Basic science tells us that sympathetic nervous system has inhibitory role on the gastrointestinal tract. This means that perilstalsis will be inhibited. This reduces the bowel movements and results in formation osf solid stool.
Nevertheless, if not watched, Kratom use can result in undesirable constipation.

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Can be used against Insomnia

Higher doses of Kratom has been shown to be sedating in action. This can help those with difficulty finding sleep. And some other use of kratom are

  • Antioxidant
  • Cognitive improvement
  • Analgesic

What are the side effects of Kratom?

Those in the medical profession will tell you that almost every substance on the surface of the earth if not properly used can be poisonous. You may be surprised to be told that too much of water or oxygen can be dangerous. Kratom like every other drug has some few side effects.

Nevertheless, it is important that restraint is practised. Most of the Kratom side effects n the internet are a creation of the media and anti-kratom crusaders.

However, it will be misguiding to say that Kratom has no side effects. It has, but few side effects. They include:

  • Pupillary constriction
  • Hyperpigmentation of the skin
  • Facial flushing
  • Tremors or loss of motor coordination.
  • Constipation.
  • Sweating.
  • Dizziness.
  • Nausea and vomiting.
  • Itching.

Is Kratom Powder Addictive?

Whether or not Kratom is addictive is very debatable. There are reports by some others that Kratom is less addictive than the classical opiods.

While other others are of the option that just like opiods, the use of Kratom is very addictive. Yet still other reports have that it can be addictive in some individuals and not in others.

All these are but proposals. There are no clear data and evidence to support any of these
In Southeast Asian countries, the Kratom is believed to very addictive that most countries like Myanmar have banned it’s use.

What are the major roles of Mitragynine

Like we mentioned, Kratom has two major active alkaloids 7-hydroxymitragynine and Mitragynine. Mitragynine is said to be the most abundant the two active alkaloids. Mitragynine acting through different opiod receptors, produces antinociceptive effects similar to those produced by other opiods drugs.

Mitragynine possesses dose-dependent pharmacological effects. Whereas stimulant effects are experienced at lower doses, opiate-like effects eg sedation are only felt when taken in higher doses.
Just like opiods, Mitragynine has been shown to have anti-inflammatory properties. These effects are potentiated through kratom’s binding and activation of opiod receptors.

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Mitragynine also has antidiarrheal, antitussive, antipyretic, euphoric, antidepressant, anxiolytic, blood pressure lowering, antidiabetic, and appetite suppressing affects.

Studies have shown that Mitragynine can be toxic to the body if not used well. Hepatoxicity and nephrotoxicity are some of the possible toxicities.

Some authors also say that on top of these, Mitragynine could cause cognitive impairments. This was according to studies done on some animal specimen e.g in a mice.

Analysis of Mitragynine In Human Body

How kratom works in body

Mitragynine use or abuse as some may call it may be detected my measuring the levels of Mitragynine and it’s metabolites in the blood.

Even the small trace amount of mitragynine in human urine can be detected by a high performance liquid chromatography coupled to an electrospray tandem mass spectrometry.
Mitragynine is quantified in human urine from 1.00-500.00 ng/mL using mitraphylline as an internal standard.

Two of its metabolites, 5-desmethylmitragynine and 17-desmethyldihydromitragynine) and the related active, alkaloid 7-hydroxy-mitragynine, are simultaneously qualitatively monitored.

The presence of analytes are confirmed by an information-dependent acquisition-enhanced product ion procedure generating full fragmentation data used to positively identify detected analytes.

Best way to take Kratom. Should you take Kratom on an empty stomach? Or should it be taken with food?

Taking Kratom on an empty stomach is highly recommended. Reports have that most side effects of Kratom are potentiated by taking kratom together with food.

However, they are individuals that can’t just do without food. May be due to high energy requirement in them even body builders they may be excused from this rule. Interestingly, they report no issues when they take Kratom together with food. How this happens is not completely understood.

The Toss and Wash Method

  • This is one of the popular methods of taking kratom. Although Kratom has very unpleasing taste, some users still favorite this method.
  • It’s very simple, what you need is just Kratom, water and a spoon. The first step involves taking a measured volume kratom.
  • This is followed by scooping the kratom into your mouth. Kratom sticks and clumps onto your tongue and side of your mouth.
  • Then you follow closely with a glass of water, juice or any liquid and toss the powder around almost like you are swishing mouthwash.
  • Kratom will be freed from the sides of the mouth and the tongue. Then you can now swallow your good stuff.
  • It is important to remember to brush the teeth after a toss and wash, otherwise you will be sponsoring the damage of your teeth.
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Mixing Kratom With Drinks

There are reports that some Kratom users love it when it’s mixed with other drinks eg alcohol. This can be surprising cause basically there is no need of mixing Kratom with other drinks.
There are reports of users who felt very ill after mixing Kratom with alcohol yet still they are those that enjoy the mix.

In addition, some users also report the loss in the urge to drink after smoking or chewing Kratom.

Taking Kratom Powder In Capsule Form

Kratom with Tea

  • Some Kratom users prefer using it as tea. Reports shows that when used in tea, it takes a very short time for you to steep up.
  • The flavor and strength of Kratom can be reduced when too much water is used.
  • In comparison to powder methods, kratom tea has a different profile of effects. Reports show more stimulating with kratom tea.
  • Additionally, the pain-relieving effects are very slightly reduced when it is consumed in this manner.
  • More importantly enough, Kratom tea is the rapidly absorbed and digested. Some reports claim the mood-boosting and euphoric effects are increased in comparison to the standard effects of kratom.


From the above discussion, it goes without saying that Kratom has very promising health benefits that need to be explored.
It is needless for Scientists and medical professionals all over the world to demonize the use of Kratom without doing adequate research.
If they meant well, they could have explored the medicinal values of Kratom and possible use of Kratom in managing different health conditions like anxiety.
Research and Scientific studies on the potential benefits or side effects of Kratom is the only sure way to authorizing or banning it’s use.
It’s laughable to see different countries ban the use of Kratom while authorizing the use of other substances eg tobacco.
Kratom may have few side effect, but like we have shown has numerous benefits too that only need to be explored.

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  • Kratom works as a stimulant drug. It makes me more alert and gives my body more energy physically. It also reduces the physical and emotional pain giving me calmness and easy time. This way you should know that it’s an addictive drug.

    • Absolutely yes, with all the materials in place it is easy to process and make your own powder. Dried leaves can be grinned using the coffee grinder or fruit blenders at a high speed to give a fine powder. It is also bought as a product from dealers.

    • Truly it has different colors depending on the climatic area around the areas of origin. However, these types are known to have distinct effects on the body. Red kratom is believed to be best for realizing stress and anxiety, white for energizing, green for wakefulness, yellow for mood lifting and alertness.

  • Well, after having used variety painkillers for quite some time now, all have failed to get me the relief I needed. However, with a littlebit of research here Ihave come across one called kratom. My search for the fact presented here show that it is one of the modern effective drugs thatworks magic in relieving pain.

  • Kratom is a stimulant drug at low doses but any alterations of the required dose lead to sedating. It is an ancient herbal drug mostly in Asia. Has been used for medical purposes as a painkiller, recreational drug, tested and tried for arthritis and diarrhea.

    • This drug can be taken raw and green or even when the leaves have been dried. It can be crushed into powder and mixed with water as a solution. Any other liquid goes well with it like fruit juice, milk and any other that makes it tastier.

  • Thinking of the Legality of this drug. Is it one that I can get in the local market or it is not legally approvedfor as a pharmaceutical sale?

    • It has not been challenged in any of the existing drug boards across Asia and Europe. This means it is freely sold within and beyond the said countries of origin. It can also be found in the local pharmacies sold over the counter with a prescription from a doctor.

  • This is a product you can get from Amazon and other online selling sites plus the mixture ratio and usage. What you should remember is that it has effects to you the user and thus you should control and regulate the usage to avoid addiction.

  • I’m a long-term Kratom user (3-4 years). It is definitely addictive, though I’d say no more so than caffeine (which I’m also addicted to). Side effects I’ve experienced after an extended period without use are diarrhea, stomach cramps, irritableness, anxiousness, and lack of motivation. Also, the symptoms of whatever you’re taking Kratom for return. I’d say quitting caffeine use is way more unpleasant (especially for those around me) than Kratom. So, don’t think that if you use Kratom you’ll eventually be rimming strangers to support your habit. You can stop if you can’t afford it anymore.
    For me, the positives of Kratom use vastly outweigh the negatives. My only real complaint is the relatively high cost. It can be expensive if you insist on using capsules instead of the powder. But, considering I can actually function as a human being thanks to Kratom, it’s a price I’m willing to pay. My quality of life has improved so much, I don’t know what I would do without it.

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